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Leukocyte cell-derived chemotaxin 2 inhibits development of atherosclerosis in mice

摘要:Leukocyte cell-derived chemotaxin 2 (LECT2), a multifunctional hepatokine, is involved in many pathological conditi ons. However, its role in atherosclerosis remains undefined. In this study, we admimistered vehicle or LECT2 to male Apoe^-/- mice fed a Western diet for 15 weeks. Atherosclerotic lesions were visualized and quantified with Oil-red O and hematoxylin staining. The mRNA expression levels of MCP-1, MMP-1, IL-8 IL-1β, and TNF-a were analyzed by quantitative real-time polymerase chain reaction. Serum TNF-a, IL-1β, IL-8, MCP-1, and MMP-1 concentrations were measured by en zyme-li nked immuno sorbent assay. CD68, CD31, and a-SMA, markers of macrophages, endothelial cells, and smooth muscle cells, respectively, were detected by immuno staining. Results showed that LECT2 reduced total cholesterol and low-density lipoprotein concentrations in serum and inhibited the development of atherosclerotic lesions, accompanied by reductions in inflammatory cytokines and lower MCP-1, MMP-1, TNF-a, IL-8, and IL-1β mRNA abundanee. Furthermore, LECT2 decreased CD68, but in creased cr SMA in atherosclerotic lesi ons, suggesting an in crease in smooth muscle cells and reduction in macrophages. In summary, LECT2 inhibited the development of atherosclerosis in mice, accompanied by reduced serum total cholesterol concentration and lower inflammatory responses.

關鍵詞:
  • leukocyte  
  • chemotaxin  
  • atherosclerosis  
  • inflammation  
  • lipid  
  • metabolism  
作者:
Wen-Ming; He; Ting; Dai; Jiong; Chen; Jian-An; Wang
單位:
Department; of; Cardiology; of; the; Second; Affiliated; Hospital; Zhejiang; University; School; of; Medicine; Hangzhou; Zhejiang; 310009; China; Department; of; Cardiology; the; Affiliated; Hospital; of; Medical; School; of; Ningbo; University; Ningbo; Zhejiang; 315010; China; Laboratory; of; Biochemistry; and; Molecular; Biology; School; of; Marine; Sciences; Meishan; Campus; Ningbo; University; Ningbo; Zhejiang; 315832; China
刊名:
動物學研究

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期刊名稱:動物學研究

動物學研究雜志緊跟學術前沿,緊貼讀者,國內刊號為:53-1229/Q。堅持指導性與實用性相結合的原則,創(chuàng)辦于2014年,雜志在全國同類期刊中發(fā)行數(shù)量名列前茅。